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A measure of residual inflammatory risk may be a powerful predictor of future cardiovascular events

New evidence released today from a study of 31,245 patients already taking statin therapy indicates that inflammation may be a more powerful predictor of risk of future cardiovascular events-;such as heart attack and stroke -; than "bad" cholesterol.
Paul Ridker Emily Henderson American College Of Cardiology Mass General Brigham American College Discovery Industry Focus

Fixed-dose combination therapy provides better results than monotherapy for pulmonary hypertension

Patients with pulmonary arterial hypertension (high blood pressure in the arteries that supply the lungs, also called PAH) had approximately double the reduction in pulmonary vascular resistance (PVR) if they took the PAH medications macitentan (10 mg) and tadalafil (40 mg) together in a single tablet rather than either drug alone, according to research being presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.
United States Kelly Chin Emily Henderson Ut Southwestern Medical Center Janssen Pharmaceutical Company Of Johnson World Health Organization

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Mutation in a single non-coding gene found to be the source of multisystemic smooth muscle dysfunction syndrome

A team of investigators from Massachusetts General Hospital, a founding member of Mass General Brigham and Mass General for Children has identified-; for the first time-; the mutation in a single non-coding gene of a young patient responsible for the extremely rare disease known as multisystemic smooth muscle dysfunction syndrome, which causes profound cerebrovascular, gastrointestinal and urologic impairment.
United States David Sweetser Mark Lindsay Lino Cardenas Patricia Musolino Lauren Briere

Digital cognitive behavioral therapy reduces blood sugar levels in patients with diabetes

People with Type 2 diabetes who were given a smartphone app that delivers personalized cognitive behavioral therapy (CBT) saw significantly greater reductions in their blood sugar and less need for higher doses of diabetes medications at six months compared with those who only received standard diabetes care and a control app, in a study presented at the American College of Cardiology's Annual Scientific Session Together With the World Congress of Cardiology.
United States Marcp Bonaca Emily Henderson University Of Colorado University Of Colorado School Medicine Clinical Research

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