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Embryonic immune sensor could key to creating patient-derived blood stem cells

A microbial sensor that helps identify and fight bacterial infections also plays a key role in the development of blood stem cells, valuable new insight in the effort to create patient-derived blood stem cells that could eliminate the need for bone marrow transplants.
United States Iowa State University Elizabeth Snella Clyde Campbell Karin Dorman Abigail Gorden

Autopsy study provides new insights into yellow fever's impact on the heart

To fill gaps in knowledge of yellow fever (YF), a group of researchers in Brazil affiliated with the Department of Pathology at the University of São Paulo's Medical School (FM-USP), Hospital das Clínicas (HC, the hospital complex run by FM-USP), the Heart Institute (InCor, linked to HC) and Emílio Ribas Institute of Infectious Diseases (IIER) decided to study the pathogenesis of YF-associated heart injury.
United States Fernando Rabioglio Giugni Jean Charles Faget Amaro Nunes Duarte Neto Department Of Pathology Lancet Group

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Association of genetically proxied PDE5 inhibition with measures of fertility, sexual behavior, and wellbeing

Researchers performed a two-sample Mendelian randomization analysis to investigate the associations between genetically proxied suppression of PDE5, a recognized pharmacological target for erectile dysfunction, fertility, subjective wellness, and sexual behavior.
United Kingdom International Consortium For Blood Pressure International Consortium Blood Pressure United Kingdom Biobank Elsworth United Kingdom Biobank

Association of genetically proxied PDE5 inhibition with measures of fertility, sexual behaviour, and wellbeing

Researchers performed a two-sample Mendelian randomization analysis to investigate the associations between genetically proxied suppression of PDE5, a recognized pharmacological target for erectile dysfunction, fertility, subjective wellness, and sexual behavior.
United Kingdom International Consortium For Blood Pressure International Consortium Blood Pressure United Kingdom Biobank Elsworth United Kingdom Biobank

Novel stem cell treatment could revolutionize liver disease management

Mortality related to end stage liver disease is ranked as the 12th most common cause of death in the U.S. Liver transplantation remains the only treatment for end stage liver disease, but there is a critical shortage of organ donors, necessitating a dire need for new forms of treatment.
United States Boston University Valerie Gouon Evans Boston University Liver Biologist Program Boston Medical Center Boston University Chobanian

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