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IMAGE: Marked differences in gene activity were identified in the anterior portion of the hippocampus, which points downward toward the face, and the posterior, which points upward toward the back of... view more
Credit: Melissa Logies
DALLAS - May 28, 2021 - A study of gene activity in the brain's hippocampus, led by UT Southwestern researchers, has identified marked differences between the region's anterior and posterior portions. The findings, published today in
Neuron, could shed light on a variety of brain disorders that involve the hippocampus and may eventually help lead to new, targeted treatments.
"These new data reveal molecular-level differences that allow us to view the anterior and posterior hippocampus in a whole new way," says study leader Genevieve Konopka, Ph.D., associate professor of neuroscience at UTSW.
Study identifies the key genes in the brain involved in encoding memories
UT Southwestern scientists have identified key genes involved in brain waves that are pivotal for encoding memories. The findings, published online this week in
Nature Neuroscience, could eventually be used to develop novel therapies for people with memory loss disorders such as Alzheimer’s disease and other forms of dementia.
Making a memory involves groups of brain cells firing cooperatively at various frequencies, a phenomenon known as neural oscillations. However, explain study leaders Bradley C. Lega, M.D., associate professor of neurological surgery, neurology, and psychiatry, and Genevieve Konopka, Ph.D., associate professor of neuroscience, the genetic basis of this process is not clear.
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IMAGE: Above illustration shows a neuron (green) ensheathed by an oligodendrocyte (purple) with "activated " genetic material (DNA) in each cell's nucleus. Differences in each cell type's active DNA may underlie human... view more
Credit: Melissa Logies
DALLAS - March 10, 2021 - UT Southwestern scientists have identified key genes involved in brain waves that are pivotal for encoding memories. The findings, published online this week in
Nature Neuroscience, could eventually be used to develop novel therapies for people with memory loss disorders such as Alzheimer's disease and other forms of dementia.
Making a memory involves groups of brain cells firing cooperatively at various frequencies, a phenomenon known as neural oscillations. However, explain study leaders Bradley C. Lega, M.D., associate professor of neurological surgery, neurology, and psychiatry, and Genevieve Konopka, Ph.D., associate professor of neuroscience, the genetic basis of this process is not clear.