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 E-Mail The inhibition of pathological protein-protein interactions is a promising approach for treating a large number of diseases, including many forms of cancer. A team of researchers has now developed a bicyclic peptide that binds to beta-catenin a protein associated with certain types of tumor. The secret of their success is the cyclic nature and the hairpin shape of the peptide, which mimics a natural protein structure, they report in the journal Angewandte Chemie. Because of the extensive protein regions involved in protein-protein interactions, therapeutic approaches involving small molecules are often unsuccessful. Protein mimetics are alternatives that imitate the spatial structure of binding segments of natural protein binding partners. Although beta-sheets protein structures made of several stretched out peptide chains arranged side by side, resembling a sheet of paper folded like an accordion often play a role in the interaction of proteins, they have rarely been us

United kingdomTomn grossmannAstrazeneca cambridgeAngewandte chemieNapoli federicoVrije universiteit amsterdamஒன்றுபட்டது கிஂக்டம்ந்யாபலீ ஃபெடரீகொ