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Use of immunosuppressants for inflammatory rheumatic diseases and the associated risk of severe COVID-19

A recent study posted to the medRxiv* preprint server investigated the risk of severe/fatal coronavirus disease 2019 (COVID-19) in patients treated with immunosuppressants for inflammatory rheumatic diseases (IRD).
United Kingdom Glasgow City Public Health Scotland National Health Service Image Credit Rapid Epidemiological Analysis

Antibodies become more powerful for at least six months after COVID-19 vaccination

For at least six months after COVID-19 vaccination, antibodies produced by immune cells become steadily more formidable and more precisely targeted against the virus that causes COVID-19, according to a study of the antibody response to the Pfizer-BioNTech vaccine by researchers at Washington University School of Medicine in St. Louis.
Ali Ellebedy Julianq Zhou Wooseob Kim Gregory Siskind Herman Eisen Emily Henderson

Researchers generate stable cell lines capable of producing various hepatitis B virus genotypes

A new study created stable cell lines capable of producing different genotypes of the hepatitis B virus (HBV), advancing understanding of each type's distinct virological features, treatment responses, and infectivity that could lead to new therapies against a virus infecting humans as far back as 4,500 years ago.
Emily Henderson B Cell Hepatitis B Hepatitisb Virus N Vitro N Vivo

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Memory B cells induced by mRNA vaccine may help generate antibodies against Omicron

In a recent research article published in the journal of Science Immunology, a team of researchers from Japan performed longitudinal analysis on the cellular composition of receptor-binding domain (RBD) memory B cell subsets and its antibody binding and neutralizing activity against the Beta, Delta, and Omicron variants following the second dose of a messenger ribonucleic acid (mRNA) vaccine.
Kateryna Kon Shutterstock Science Immunology Image Credit Coronavirus Disease Covid 19 B Cell Monoclonal Antibody

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Researchers at University Hospitals Seidman Cancer Center and Case Western Reserve University have developed a novel approach to chimeric antigen receptor (CAR) T-cell therapy for B-cell cancers that triples the targeted antigens on cancer cells – a "back up" approach that promises to greatly reduce the potential for antigen escape currently found in CAR T therapies that solely target CD19.
Stan Gerson Emily Henderson National Center Nature Communications Case Comprehensive Cancer Center Drug Administration

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