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Potentially serious side effect reported after CAR-T cell therapy for multiple myeloma

Mount Sinai scientists have become the first to report a potentially serious side effect related to a new form of immunotherapy known as CAR-T cell therapy, which was recently approved for the treatment of multiple myeloma.
Samir Parekh Oliver Van Oekelen Miriam Merad Emily Henderson Mount Sinai Human Immune Monitoring Center Icahn School Of Medicine At Mount Sinai

Scientists develop and characterize variant-specific vaccines against SARS-CoV-2

In a recent study conducted at Yale University, USA, scientists have investigated the immunogenicity of mRNA-based coronavirus disease 2019 (COVID-19) vaccine candidates encoding the spike proteins of different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants. The findings reveal that the vaccines induce robust immune responses against SARS-CoV-2 variants. The study is currently available on the bioRxiv* preprint server.
South Africa United States Yale University Coronavirus Disease Covid 19 Ars Cov 2 B Cell

CNN Anderson Cooper 360 December 7, 2021 02:32:00

Shows that people who have recovered from covid have strong immunity and i mean b-cell data just this week actually and t-cell data, those are called memory cells. antibodies will actually be higher if youve had a severe infection. lower if youve had a mild infection. but they come down after vaccination anyway. its about what is cellular memory. >> isnt it, dr., gandhi, a very individualized process? in other words, millions have gotten the vaccine and theres a ton of data as to what we can exp...
T Cell Data Memory Cells B Cell Isnt It

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Characterization of B-cell receptor repertoires in COVID-19 patients

In a new study published in the journal Human Immunology, scientists sought to better understand how B-cell immune repertoire changes over time during SARS-CoV-2 infection by comprehensively characterizing the dynamics of immunoglobin heavy chain (IGH) repertoire in COVID-19 patients.
Coronavirus Disease Human Immunology Coronavirus Disease Covid 19 B Cell Health Systems Immune Response

Importance of cross-neutralizing antibodies against SARS-CoV-2 variants

A new study published in the journal mBio investigates different antibodies from convalescent donors that bind three separate domains of the SARS-CoV-2 spike. The results of this study suggest that the individuals exposed to the SARS-CoV-2 from the first wave have neutralizing antibodies against current variants.
Antibodies Targeting Distinct Epitopes Image Credit Corona Borealis Studio Total Igg Middle East Coronavirus Disease Covid 19

GABA secreted by B-cells blunts the body's cytotoxic T-cell-based response to tumors

A group of scientists led by researchers from the RIKEN Center for Integrative Medical Sciences have discovered that B-cells, a type of immune cell, secrete the neurotransmitter GABA, and also found that the GABA secreted by the B-cells promoted the emergence of anti-inflammatory macrophages, blunting the body's cytotoxic T-cell-based response to tumors.
Baihao Zhang Emily Henderson Integrative Medical Sciences Integrative Medical Sidonia Fagarasan Immune Response

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