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Scientists genetically decode rare kidney disease

Scientists genetically decode rare kidney disease
medicalxpress.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from medicalxpress.com Daily Mail and Mail on Sunday newspapers.

City ofUnited kingdomBodo beckDavid ausserhoferMax delbrJanine altmBerlin institute of health at charitUniversity hospital cologneGenomics platformBerlin instituteMedical systems biologyNature methodsGenome medicine

Rare Kidney Disease Is Genetically Decoded

Rare Kidney Disease Is Genetically Decoded
eurasiareview.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurasiareview.com Daily Mail and Mail on Sunday newspapers.

City ofUnited kingdomBodo beckMax delbrJanine altmUniversity hospital cologneBerlin institute of health at charitGenomics platformBerlin instituteMedical systems biology

Long-read sequencing reveals new details of Bartter syndrome type 3

Bartter syndrome type 3 is the result of several structural variants in the genome. By using long-read sequencing, Janine Altmüller and her team from the Max Delbrück Center, the BIH and University Hospital Cologne mapped out the rare disease in unprecedented detail.

City ofUnited kingdomBodo beckMegan craigMax delbrJanine altmBerlin institute of health at charitUniversity hospital cologneGenomics platformBerlin instituteMedical systems biologyKidney diseaseBartter syndromeRare disease

Rare kidney disease is genetically decoded

Rare kidney disease is genetically decoded
eurekalert.org - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from eurekalert.org Daily Mail and Mail on Sunday newspapers.

City ofUnited kingdomJanine altmBodo beckMax delbrGerman centerMinistry of educationCardiovascular researchBerlin institute of healthHelmholtz association max delbrClinical research centerUniversity hospital cologneBerlin institute of health at charitGenomics platformBerlin instituteMedical systems biology

Low binding affinity improves vaccine efficac

Conventional vaccines usually contain antigens – components of the respective pathogens – that bind to receptors on the surface of their target cells in order to trigger the disease. Scientists at the Berlin Institute of Health at Charité (BIH) and the Max Delbrück Center have now discovered that antigen variants with low receptor binding can be advantageous for the development of vaccines. The research team has succeeded in producing a new vaccine against the SARS-CoV-2 coronavirus by identifying spike protein mutants that lack binding affinity. The scientists have now published their findings in the European Journal of Immunology.

Max delbrChristoph ratswohlStiftung charitStefanie seltmannBerlin institute of health at charitMinistry of educationHead of communicationsMethod of researchBerlin instituteEuropean journalKathrin de la rosaJohanna quandt professorshipTranslational immune mechanismsQuandt professorshipsJohanna quandt professorsFederal ministry