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he didn't look like the son that i had. he went from being such a happy, confident, clever boy to this shell of a person. i didn't know who he was any more. in april 2023, ryan died at the age of 26. ketamine is really popular here in bristol, so much so there's even a term "bristol bladder". that's to refer to the impact ketamine can cause to the bladder if you take a lot of it. southmead hospital, like others across the country, set up a specialist clinic last year to help patients struggling with the impact of chronic ketamine use. why ketamine seems to be the drug of choice, it's cheap to buy, i think people don't realise that it has detrimental effects to the bladder and i think it's viewed as sort of a safe drug by people. back with beth and jay, who say they had no idea of the impact ketamine can have when they first started using and wish they'd never tried it.

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the drug is widely used as an anaesthetic, and a sedative. but increasingly it�*s also misused as a recreational drug — and addiction rates are soaring. here�*s rachel stonehouse. from the minute you wake up... it�*s a saturday night in bristol. we are with beth and her friend we are calling jay, as he wants to be anonymous. they are both in their 20s and chronic ketamine users, after trying it as teenagers. i was 1a years old and somebody had some in the classroom and i had a little bit at the back of the classroom. that was the first time i had it. what is the physical impact for you now of taking ketamine? can't work, yeah, i can't do anything, i can't feed myself or go and get a drink. yeah, it really disables you completely. i can�*t walk 50 metres without either needing to sit down or needing to run to the toilet. ketamine use is estimated to have more than doubled since 2016 in england and wales, and ketamine addiction has quadrupled in that time. and, although deaths linked to ketamine are rare, they are also on the rise.

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why ketamine seems to be the drug of choice, it's cheap to buy, i think people don't realise that it has detrimental effects to the bladder and i think it's viewed as sort of a safe drug by people. back with beth and jay, who say they had no idea of the impact ketamine can have when they first started using and wish they'd never tried it. i'm hoping that i'll get back into work and one day be a person that has recovered from this really rubbish journey that i've been on. rachel stonehouse, bbc news. to find out about more of the risks associated with kaagman, i spoke earlier to someone from the us that make you an office for drugs and crime.

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why ketamine seems to be the drug of choice, it�*s cheap to buy, i think people don�*t realise that it has detrimental effects to the bladder and i think it�*s viewed as sort of a safe drug by people. back with beth and jay, who say they had no idea of the impact ketamine can have when they first started using and wish they�*d never tried it. i�*m hoping that i�*ll get back into work and one day be a person that has recovered from this really rubbish journey that i�*ve been on. rachel stonehouse, bbc news. let�*s speak to dr mohammed belal from the british association of urological surgeons. thank you so much for being with us. give me a sense of how often you are seeing young people with the sort of

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bladder problems with addiction to ketamine soaring. from the minute you wake up... it's a saturday night in bristol. we are with beth and her friend we are calling jay, as he wants to be anonymous. they are both in their 20s and chronic ketamine users, after trying it as teenagers. i was 1a years old and somebody had some in the classroom and i had a little bit at the back of the classroom. that was the first time i had it. what is the physical impact for you now of taking ketamine? can't work, yeah, i can't do anything, i can't feed myself or go and get a drink. yeah, it really disables you completely. i can't walk 50 metres without either needing to sit down or needing to run to the toilet. ketamine use is estimated to have more than doubled since 2016 in england and wales, and ketamine addiction has quadrupled in that time. and, although deaths linked to ketamine are rare, they are also on the rise.

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of the drug ketamine. ketamine is widely used in the nhs as an anaesthetic, sedative and pain reliever, but increasingly it's also misused as a recreational drug, and addiction rates are soaring. here's rachel stonehouse. from the minute you wake up... it's a saturday night in bristol. we are with beth and her friend we are calling jay, as he wants to be anonymous. they are both in their 20s and chronic ketamine users, after trying it as teenagers. i was 1a years old and somebody had some in the classroom and i had a little bit at the back of the classroom. that was the first time i had it. what is the physical impact for you now of taking ketamine? can't work, yeah, i can't do anything, i can't feed myself or go and get a drink. yeah, it really disables you completely. i can't walk 50 metres without either needing to sit down or needing to run to the toilet. ketamine use is estimated to have

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that's to refer to the impact ketamine can cause to the bladder if you take a lot of it. southmead hospital, like others across the country, set up a specialist clinic last year to help patients struggling with the impact of chronic ketamine use. why ketamine seems to be the drug of choice, it's cheap to buy, i think people don't realise that it has detrimental effects to the bladder and i think it's viewed as sort of a safe drug by people. back with beth and jay, who say they had no idea of the impact ketamine can have when they first started using and wish they'd never tried it. i'm hoping that i'll get back into work and one day be a person that has recovered from this really rubbish journey that i've been on. rachel stonehouse, bbc news. in less than two weeks' time, voters across england and wales go

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>> complicated i mean, you would not want to be a policymaker right now at the white house or the state department because you're trying to juggle all these things like, here's more context. >> the hostage negotiations hamas has rejected them. >> they are going nowhere there is no peace agreement deal going on with hezbollah on wednesday 14, israeli soldiers, six seriously injured by drone and missile strikes from his bullet into iran. i mean, like all of this, and then they're trying to thread the needle to a two-state solution by all this stuff. and none of the things at the beginning of that process are going well oh crisis averted but all the problems underlying problems are still, here, are still there. >> and israel has been facing mounting criticism from the world, from one of their most important ally as the united states, over their prosecution of the war in gaza. and yet over the last week, beth, we saw its allies come to its

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red lines at the two countries understood twin each other. those are blurred so if we're not closer to regional escalation, certainly the cost of it became a lot clearer over the past week absolutely. >> nic robertson, force in jerusalem. thanks so much for that reporting. and i want to bring in that sandra in national security analysts, former deputy director of national intelligence, beth, we're glad you're here with us. listening to nick's reporting there. i think so many people around the world are wondering, what does this mean now, where are how higher the tensions and what's the risk of escalation? what's your assessment i think if we pull back a little bit and say, where are we right now in terms of this 30,000 foot level in the past few weeks beaks we've seen this context changed completely all these red lines that nick just brought up. >> they've been broken. the norms of behavior between israel and iran have now

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