email article
Anti-inflammatory oral drug colchicine improved COVID-19 outcomes for patients with relatively mild cases, according to certain topline results from the COLCORONA trial announced in a brief press release.
Overall, the drug used for gout and rheumatic diseases reduced risk of death or hospitalizations by 21% versus placebo, which approached statistical significance.
However, there was a significant effect among the 4,159 of 4,488 patients who had their diagnosis of COVID-19 confirmed by a positive PCR test:
25% fewer hospitalizations
44% fewer deaths
If upheld after peer review a full manuscript was posted two days later to the medRxiv preprint server colchicine could become the first oral drug proven to benefit non-hospitalized patients with COVID-19.
Lateral flow tests detect most infectious COVID-19 cases, Oxford researchers find pmlive.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from pmlive.com Daily Mail and Mail on Sunday newspapers.
email article
The COVID-19 pandemic adversely impacted the detection and management of colorectal cancer (CRC) across England, according to a population-based study.
The number of people being referred to hospitals with suspected lower gastrointestinal cancer, and the number subsequently diagnosed, fell sharply during the first lockdown in March and a deficit persisted until September, which translated to >3,500 fewer people than expected starting treatment in the period April to October 2020, based on levels for the same period in 2019, reported Eva J.A. Morris, PhD, of the Big Data Institute at the University of Oxford, and colleagues. As delays in diagnosis allow tumours to continue to grow and advance, this bottleneck in the diagnostic pathway is likely to have a profoundly detrimental impact on colorectal cancer outcomes in England, they wrote in
Research Article
Accelerometer measured physical activity and the incidence of cardiovascular disease: Evidence from the UK Biobank cohort study
Rema Ramakrishnan, Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing
Affiliations Nuffield Department of Women’s and Reproductive Health, University of Oxford, Oxford, United Kingdom, University of New South Wales, Sydney, Australia Roles Investigation, Methodology, Resources, Validation, Writing – review & editing
Affiliations Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, United Kingdom, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom, National Institute of Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS F