Organic conductive polymers are prime candidates for the on demand or controlled release of neurotrophic proteins which can enhance the electrode-neural interface. In this study, bipolar electrochemistry (BPE) is employed to provide a wireless electrical stimulation that avoids the need for the direct physical connection necessary for conventional approaches. Brain-derived neurotrophic factor (BDNF) was incorporated into polypyrrole (PPy) with poly (2-methoxy-5 aniline sulfonic acid) (PMAS) as a dopant during the course of electrochemical synthesis. The synthetic PPy-PMAS-BDNF material acts as the bipolar electrode and is placed within an electric field generated by two driving electrodes. Controlled release of BDNF is demonstrated, which is wireless powered by BPE. This is likely due to the wirelessly activated redox reactions which induce gaps/channels within the structure. Quantification of the BDNF reveals significant differences in the controlled-release properties of the films dr
The increased level of interest in the miniaturization of analytical devices has led to a focus on exploring new and inexpensive materials. This dissertation aims to investigate the combination of nascent textile-based microfluidics with electrophoretic control principles to develop the new groundbreaking textile-based electrofluidic systems for the direct and rapid characterization of analytes separated from complex mixtures and matrices. Capillary electrophoretic systems typically comprise inaccessible and fully enclosed micro-capillary or microchannels, with limited sample loading capacities and no direct access to the solutes within. Herein, we investigate the use of textile constructs as electrophoretic substrates to provide an open and surface-accessible separation platform. The techniques commonly utilized in capillary electrophoresis, including electrophoretic separation, isotachophoretic (ITP) preconcentration, and surface functionalization, were investigated using textile sub
Electrochemical stimulation (ES) promotes wound healing and tissue regeneration in biomedical applications and clinical studies and is central to the emerging field of electroceuticals. Traditional ES such as deep brain stimulation for Parkinson’s disease, utilises metal electrodes that are "hard wired" to a power supply to deliver the stimulation. Bipolar electrochemistry (BPE) introduces an innovative approach to cell stimulation that is wireless. Developing conducting polymers (CPs)-based stimulation platforms wireless powdered by BPE bipolar will provide an exciting new dimension to medical bionics. In this project, Chapter 2 deals with development of a bipolar electrochemical activity testing system and bipolar electrochemical stimulation (BPES) system. Then, bipolar electroactive and biocompatible CPs grown on FTO substrate are successfully synthesised, modified, and characterised in Chapter 3 and Chapter 4 using the above systems prior to using for wireless cell stim