Comparison of LPS and MS-induced depressive mouse model: behavior, inflammation and biochemical changes | BMC Psychiatry
Depression is a mental disease involving complex pathophysiological mechanisms, and there are many ways to establish depressive mouse models. The purpose of this study is to comprehensively compare the behavioral changes and its mechanism induced by two different models. This study established two depressive mouse models by maternal separation (MS) or lipopolysaccharide (LPS) administration, and added fluoxetine treatment group respectively for comparison. MS induced more apparent anxiety-like b...
United States San Diego Merck Millipore Laboratory Animals National Institutes Of Health China Medical University
Source: biomedcentral.com