Brian Grone News Today

New research sheds light on protective mechanisms of the “Christchurch mutation.” Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the “Christchurch mutation” can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most co

<p>Scientists at Gladstone Institutes have discovered that APOE4-producing neurons release an immune signaling molecule called HMGB1 at much higher rates than neurons producing other APOE variants. Upon release, HMGB1 activates brain immune cells called microglia, which then trigger inflammation and the degeneration of neurons.</p>

/PRNewswire/ -- Of all the known genetic risk factors for late-onset Alzheimers disease, the strongest is a gene for the protein called ApoE4. People with one...

/PRNewswire/ -- The race to develop drugs to treat Alzheimers disease, which currently affects an estimated 6 million Americans, has been slow-going. Now,...