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Frontiers | GPX7 Is Targeted by miR-29b and GPX7 Knockdown Enhances Ferroptosis Induced by Erastin in Glioma

Background Glioma is a lethal primary tumor of central nervous system. Ferroptosis is a newly identified form of necrotic cell death. Triggering ferroptosis has shown potential to eliminate aggressive tumors. GPX7, a member of glutathione peroxidase family (GPXs), has been described to participate in oxidative stress and tumorigenesis. However, the biological functions of GPX7 in glioma are still unknown. Methods Bioinformatics method was used to assess the prognostic role of GPX7 in glioma. CCK...
United States United Kingdom Dunfa Peng Biochim Biophys Acta Silva Mcda Chin Neurosurg

Basal epithelial cells in treating prostate cancer

15 Basal epithelial cells are a blood–prostate barrier between luminal cells and basement membrane 16 but are absent in prostate carcinoma. 17–19 Loss of basal epithelial cells is a characteristic of prostate carcinoma 20,21 and one of the diagnostic criteria of prostate cancer, 19 suggesting that some essential connections might exist between basal epithelial cells and prostate cancer cells. So, we put out a question regarding whether basal epithelial cells could suppress migration or inva...
United States Peprotech Company United States Gibco Company United States Cell Bioscience Inc Cell Co China University Of Technology School Medicine

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