Page 10 - Cell Cycle News Today

City of Hope, a world-renowned cancer research and treatment center, has identified how cancer cells in patients with early-stage breast cancer change and become resistant to hormone or combination therapies, according to a new study published in Nature Cancer.

Aging published "Cdkn1a transcript variant 2 is a marker of aging and cellular senescence" which reported that cellular senescence is a cell fate response characterized by a permanent cell cycle arrest driven primarily the by cell cycle inhibitor and tumor suppressor proteins p16Ink4a and p21Cip1/Waf1.

Oncotarget published "Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology" which reported that the authors comprehensively investigated miRNA-193a-3p's mode of action in a panel of human cancer cell lines, with a variety of genetic backgrounds, using 1B3, a synthetic microRNA mimic

Mathematical modeling is a tool with the potential to uncover fine detail of the complex cell signaling networks involved in managing the eukaryotic cell cycle.

Huntingtin interacting protein-1 interacting protein promotes tumor progression through regulating DNA replication pathways in non-small cell lung cancer

Circ_HIPK3 knockdown blocked cholangiocarcinoma malignant development partly via regulating the miR-148a-3p/ULK1 pathway

USP7 inhibitors could increase the anticancer effects of CDK1 compounds in cancer patients Understanding the components that control cell division is fundamental to understanding how life works and how alterations in this delicate process can cause diseases such as cancer. It was precisely the discoveries of "key regulators of the cell cycle" and their implications for processes such as cancer, that won the British scientists R. Timothy Hunt and Paul M. Nurse and the American scientist Leland H...

Study solves mystery of how cells measure their size Scientists have searched for years to understand how cells measure their size. Cell size is critical. Its what regulates cell division in a growing organism. When the microscopic structures double in size, they divide. One cell turns into two. Two cells turn into four. The process repeats until an organism has enough cells. And then it stops. Or at least it is supposed to. The complete chain of events that causes cell division to stop at the ...

13–15 Calycosin is a fat-soluble component in the dried root of Astragalus membranaceus, which are organic compounds widely found in nature. Calycosin exerts various anti-tumor activities in vitro and in vivo, 16–18 but its mechanism of action in human GC cells is not clear. In this study, we evaluated the effects of calycosin on apoptosis, the cell cycle, and migration of GC cells under ROS regulation. In addition, we also determined the roles of MAPK/STAT3/NF-κB pathways in these proces...

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