Page 2 - Cell Dev News Today

The Burden of Musculoskeletal Diseases in the United States (BMUS). Third ed. 2014. 9. Lo J, Chan L, Flynn S. A systematic review of the incidence, prevalence, costs, and activity and work limitations of amputation, osteoarthritis, rheumatoid arthritis, back pain, multiple sclerosis, spinal cord injury, stroke, and traumatic brain injury in the United States: a 2019 Update. Arch Phys Med Rehabil. 2021;102(1):115–131. doi:10.1016/j.apmr.2020.04.001 10. Puig-Junoy J, Ruiz Zamora A. Socio-econ...

163 are also involved in resistance to cisplatin, temozolomide and 5-fluorouracil via altering glycolysis in gastric cancer, glioblastoma and CRC, respectively. Interestingly, Fu et al reported that lncRNA plasmacytoma variant translocation 1 (PVT1) maintains Myc expression in Sjögren’s syndrome. This expression regulates proliferation and immune effects of CD4 + T cells by controlling glycolytic metabolism. 164 Investigating the role of the PVT1-T cell glycolysis axis in tumor models may pr...

More than thirty years after discovering Leber’s hereditary optic neuropathy (LHON) as the first maternally inherited disease associated with homoplasmic mtDNA mutations, we still struggle to achieve effective therapies. LHON is characterized by selective degeneration of retinal ganglion cells (RGCs) and is the most frequent mitochondrial disease, which leads to blindness young people, in particular males. Despite the causative mutations are present in all tissues, yet only a specific cell typ...

* 1Division of Cardiovascular Disease, Department of Medicine, The University of Alabama at Birmingham, Birmingham, AL, United States 2Molecular and Cellular Pathology, Department of Pathology, The University of Alabama at Birmingham, Birmingham, AL, United States 3Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, AL, United States 4Center for Translational Medicine, Temple University, Philadelphia, PA, United States Background: Endothelial cells (ECs) p...