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Frontiers | Whole-Genome Sequencing of SARS-CoV-2 Infection in a Cluster of Immunocompromised Children in Indonesia

Background: Thus far, Indonesia has recorded over 4,000,000 confirmed COVID-19 cases and 144,000 fatalities; 12.8% of cases have been in children under 18 years. Whole genome viral sequencing (WGS) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been demonstrated to help differentiate hospital-acquired infection from community-acquired coronavirus disease 2019 (COVID-19) infection. Our study highlighted the use of WGS to investigate the origin of infection among pediatric onc...
Jakarta Raya United States United Kingdom Sulawesi Selatan City Of Borough Of Bedford

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Frontiers | Downregulation of CD45 Signaling in COVID-19 Patients Is Reversed by C24D, a Novel CD45 Targeting Peptide

CD45, the predominant transmembrane tyrosine phosphatase in leukocytes, is required for the efficient induction of T cell receptor signaling and activation. Various studies have demonstrated that viruses can interfere with the functions of CD45 and that patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are immune-suppressed. We recently reported that the CD45-intracellular signals in peripheral blood mononuclear cells (PBMCs) of triple negative breast cancer (TNBC) patie...
United States United Kingdom Kfar Saba Tel Hashomer Dawen Yu Gen Virol

Taking a Closer Look at Microbial Friends and Foes With Intestine-on-a-Chip

  This cross section of a mouse Colon Chip shows the actin cytoskeleton of epithelial cells in magenta, the overlying mucus in yellow, and the cells nuclei in blue. The team used this chip in a comparative analysis of mouse and human microbiomes to test their different abilities to induce tolerance to the pathogen Salmonella typhimurium. Credit: Wyss Institute at Harvard University Read Time: Trillions of commensal microbes live on the mucosal and epidermal surfaces of the body and it is fir...
United States Dennis Kasper William Ellery Channing Donald Ingber Francesca Gazzaniga Harvard Wyss Institute For Biologically Inspired Engineering

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