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Researchers find α-synuclein spreads via the brain lymphatic system before aggregation in Parkinsons disease.

Parkinson’s disease is characterized by the presence of fibrils of α-synuclein. It has been shown that α-synuclein fibrils can be transmitted from neuron to neuron. However, whether α-synuclein spreading occurs before its aggregation remains unclear. Researchers from Tokyo Medical and Dental University (TMDU) showed that monomeric α-synuclein can propagate through the brain lymphatic system before it aggregates. This study might contribute to the development of new strategies to limit the ...

Researchers with the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine and four other institutions have developed a molecular test to identify the presence of brain tumors by measuring abnormal genetic material shed by tumors and circulating in cerebrospinal fluid (CSF).

Although antiretroviral therapies are the standard of care treatment for those with HIV, the drugs cannot target latent infections; however, venetoclax, a blood cancer treatment, shows promise.

Researchers with the Johns Hopkins Kimmel Cancer Center, the Johns Hopkins University School of Medicine and four other institutions have developed a molecular test to identify the presence of brain tumors by measuring abnormal genetic material shed by tumors and circulating in cerebrospinal fluid (CSF). A description of the work was published Aug. 15 in the journal Cell Reports Medicine.

Although promising, questions remain about whether this could be a ‘cure’, or just a way to limit the number of these cells in the body.

Recent findings suggest that women are more likely to suffer from asthma than men because of the absence of testosterone.

An existing blood cancer drug has shown promise in killing ‘silent’ HIV cells and delaying reinfections – a significant pre-clinical discovery that could lead to a future cure for the disease. Hidden HIV cells, known as latent infection, are responsible for the virus permanently remaining in the

An existing blood cancer drug has shown promise in killing 'silent' HIV cells and delaying reinfections – a significant pre-clinical discovery that could lead to a future cure for the disease.

TLM empowers scientists to witness the dynamics and behaviors of not only living cell populations but also individual living cells within these populations. This article discusses the role of time-lapse microscopy in efficiently studying cellular dynamics.