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Down Syndrome Ages Cells Throwing Neural Nuclei into Disarray

MIT scientists show that the extra copy of chromosome 21 in Down syndrome disrupts the 3D-genome, epigenome, and transcriptome of neural progenitor cells such that they resemble aged cells. The molecular changes result in functional deficits in cell proliferation and migration in the trisomy 21 bearing developmental cells. Treatment of patient-derived neural progenitor cells with a senolytic drug combination consisting of dasatinib and quercetin ameliorates these disruptions.
United States San Diego Anita Bhattacharyya Hiruy Meharena Li Huei Tsai University Of California

Pandemic may affect infants' brain development; coronavirus can trigger kidney scarring

The following is a summary of some recent studies on Covid-19. They include research that warrants further study to corroborate the findings and that has yet to be certified by peer review. Coronavirus infection during pregnancy does not appear to affect infants' brain function, but the pandemic itself may be having an impact, a study published on Tuesday in JAMA...
United States New York Columbia University New York State Psychiatric Institute Tjitske Jansen Dani Dumitriu

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Zika virus, drug discovery, and student projects

It's well understood in science education that students are more engaged when they work on problems that matter.  Right now, Zika virus matters.  Zika is a very scary problem that matters a great deal to anyone who might want to start a family and greatly concerns my students. I teach a bioinformatics course where students use computational tools to research biology.  Since my students are learning how to use tools that can be applied to this problem, I decided to have them apply the...
Rio De Janeiro Estado Do Rio Thomasl Madden Stephenf Altschul Zheng Zhang Webb Miller

Covid directly affects kidneys, can cause tissue scarring, claims study

It is well documented that the COVID-19 virus mainly affects the lungs, but a new study has claimed that the infection also has the capability to damage kidneys as well. According to a study by a team of German and Dutch scientists, COVID-19 causes direct cellular damage within the kidneys, contributing to tissue scarring or kidney fibrosis. The study was published in the journal Cell Stem Cell.
Tjitske Jansen Katharina Reimer Radboud University Medical Center Cell Stem Covid Life Expectancy 387155 Ovid News 324103

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