Cellular Plasticity News Today

Fibrosis is associated with various chronic and life-threatening conditions, including pulmonary fibrosis, liver cirrhosis, kidney disease, and cardiovascular diseases, among others.

Administration of ranolazine, a drug currently used to treat heart conditions, improves the efficacy of current therapies for melanoma in mouse models of the disease.

Researchers have used senescent cells as a "vaccine" that can be used as a prophylaxis and a therapeutic to prime the immune system against cancer cells, which has shown positive results in cancer models.

• Researchers at IRB Barcelona report that the induction of senescence in tumour cells strongly stimulates the immune system. • Vaccination with sene....

Cancer cells have a series of features that allow the immune system to identify and attack them. However, these same cells create an environment that blocks immune cells and protects the tumor.

Cells that have permanently stopped multiplying, so-called senescent cells, could play an important role in the fight against cancer, according to a new study in mice by researchers at Karolinska Institutet and IRB Barcelona. The study, published in the journal Cancer Discovery, found that vaccination with senescent cancer cells significantly reduced the formation of melanoma and pancreatic cancer tumors in mice.