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<p>The accumulation of misfolded or damaged proteins in long-lived, non-dividing cells like neurons are linked to neurodegenerative diseases like Alzheimer’s. A study in the journal <em>Cell </em>finds that the build-up of these toxic proteins also influences oocyte quality and female fertility. The researchers discovered that mouse oocytes have specialised structures which roam the cytoplasm and act like a clean-up crew which capture and hold onto protein aggregates, rendering them harmless. Failure to degrade the toxic proteins led to the formation of defective eggs. 3 in 5 (60%) of mouse embryos that inherited the toxic proteins failed to complete the very earlies stages of development. The study presents a new frontier to explore the underlying mechanisms of poor oocyte quality, which is the leading cause of female infertility.</p>
Barcelona
Comunidad-autonoma-de-cataluna
Spain
Gabriele-zaffagnini
Method-of-research
Centre-for-genomic-regulation
Genomic-regulation
Group-leader
Oocyte-biology
Cellular-dormancy
Endolysosomal-vesicular-assemblies
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