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Clip Anchoring Reduces Migration of Metal Stents in ERCP

Using clips to anchor a fully covered self-expandable metal stent reduces the occurrence of migration among patients with biliary strictures undergoing ERCP.

United statesXu wangHui luoXin shiFourth military medical universityXijing hospitalDigestive diseasesAmerican journalBiliary diseaseAllbladder diseaseEndoscopic retrograde cholangiopancreatographyRcp endoscopic retrograde cholangiopancreatography

Seladelpar Could Raise the Bar in PBC Treatment

The investigational agent significantly improved liver biomarkers of disease activity and symptoms of pruritus in adults with PBC enrolled in a phase 3 trial.

United statesNew havenGideon hirschfieldDavidn assisToronto centerYale school of medicineDrug administrationLiver diseaseToronto general hospitalMedscape medicalCymabay therapeuticsNew england journalLiver meetingAmerican associationDigestive diseasesYale school

Elafibranor Appears Effective, Safe for PBC

Treatment with elafibranor showed significantly greater improvements in relevant biochemical indicators of cholestasis than the placebo.

United statesKris kowdleyLiver institute northwest in seattleLiver institute northwestNew england journalWorst itch numeric rating scaleBiliary diseaseAllbladder diseaseIpid managementLiver fibrosisLiver diseaseHepatic impairmentTransplantation of the liverEpatic transplantationLiver transplantationCv risk

#VisualAbstract: Efficacy and Safety of Elafibranor in Primary Biliary Cholangitis

Click here to read this study in NEJM. ©2023 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc.

Minute medicine incAlkaline phosphatasePpar agonistPrimary biliary cholangitis

Novel Agent Seladelpar Improves Markers of PBC Activity

For 1 in 4 patients with primary biliary cholangitis (PBC) who received the investigational PPAR-delta agonist, alkaline phosphatase levels normalized.

United statesAleksander kragGideon hirschfeldOdense denmark university hospitalUniversity of southern denmarkToronto centerLiver diseaseToronto general hospitalLiver meetingAmerican associationLiver diseasesCymabay therapeuticsNorth americaSouth americaPeak pruritus numerical rating scaleSouthern denmark

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