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Central metabolic pathway runs backwards at high carbon dioxide concentrationsBiomass production by reverse citric acid cycle A research team from the University of Münster and the Technical University of Munich (TUM) has gained new insights into the citric acid cycle: At very high carbon dioxide concentrations, bacteria can also use this central metabolic pathway backwards to build useful compounds from carbon dioxide using the enzyme citrate synthase. It is possible that these findings can also be used biotechnologically.
The citric acid cycle is an important metabolic pathway that enables living organisms – from simple bacteria to humans – to generate energy by degrading organic compounds into carbon dioxide (CO₂). The first step in the cycle is usually performed by the enzyme citrate synthase, which builds citrate.