Heart failure is a common and devastating disorder for which there is no cure. Many cardiomyopathies -;conditions that make it difficult for the heart to pump blood such as dilated cardiomyopathy (DCM) and arrhythmogenic cardiomyopathy (ACM) -; can lead to heart failure, but treatments for patients with heart failure do not take these distinct conditions into account.
Imagine being able to track the muscular tiredness during a workout, as well as blood sugar levels, and determine if too much drink is consumed, all from a little gadget worn on the skin.
Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation of ceramides in the retina, resulting in progressive photoreceptor cell death and ultimately vision loss.
Researchers from the Lineberger Comprehensive Cancer Center of the University of North Carolina (UNC) have shown that a unique combination of two drugs that serve as targeted inhibitors, supplied in a nanoparticle formulation, prolong the survival of mice with medulloblastoma.