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In more than 15% of people with benign adrenal tumors, the growths produce clinically relevant levels of serum cortisol that are significantly linked with an increased prevalence of hypertension and, in 5% of those with Cushing syndrome (CS), an increased prevalence of type 2 diabetes, based on data from more than 1300 people with benign adrenal tumors, the largest reported prospective study of the disorder.

Benign adrenal tumors produce enough cortisol to cause hypertension or type 2 diabetes in more than 15% of patients in a prospective UK study.