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Virpax® Pharmaceuticals, Inc. , a company specializing in developing non-addictive products for pain management, post-traumatic stress disorder, central nervous system disorders and anti-viral...

/PRNewswire/ -- Halia Therapeutics, a clinical-stage biopharmaceutical company advancing innovative medicines to treat a broad range of diseases driven by...

This study aimed to examine the role of MCs and the early inflammatory events in the development of chronic vulvar pain in a rat model.

7 P2X receptors carry out many important functions in the central and peripheral nervous system. 8,9 Compelling evidence has shown that P2X3, P2X4 and P2X7 receptors are involved in the pathogenesis of chronic pain. 10 P2X7R exists in neurons and glial cells of the nervous system, but is mainly expressed in cells of immune origin such as monocytes, macrophages, and microglia. 11 The absence of P2X7R can completely eliminate the inflammatory and neuropathic hypersensitivity to both mechanical an...

Abstract Despite the remarkable advances in therapeutics for rheumatoid arthritis (RA), a large number of patients still lack effective countermeasures. Recently, the reprogramming of macrophages to an immunoregulatory phenotype has emerged as a promising therapeutic strategy for RA. Here, we report metabolically engineered exosomes that have been surface-modified for the targeted reprogramming of macrophages. Qualified exosomes were readily harvested from metabolically engineered stem cells by...