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CWRU, University Hospitals are part of a $3 million grant project on lung cancer, immunotherapy
CWRU, University Hospitals are part of a $3 million grant project on lung cancer, immunotherapy
Anant Madabhushi
Researchers from Case Western Reserve University and University Hospitals are part of a $3 million National Cancer Institute grant to develop artificial intelligence tools to help predict which lung cancer patients would respond to immunotherapy.
The team also includes researchers from New York University on the five-year grant. Clinical trials down the road will be our biggest test, but now we will be for the first time studying changes in the tissue-scan patterns of patients as they are being treated, and that will provide real-world context of our tools, said Anant Madabhushi, director of Case Western Reserve s Center for Computational Imaging and Personalized Diagnostics, said in a news release. Our AI tools have excelled in previous studies, but they have all be
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Case Western Reserve awarded $3 million National Cancer Institute grant to apply AI to immunotherapy
Scientists, medical researchers at Case Western Reserve, NYU Langone Health and University Hospitals using machine-learning to predict response to immunotherapy
Medical researchers from Case Western Reserve University, New York University (NYU), and University Hospitals have been awarded a five-year, $3 million National Cancer Institute grant to develop and apply artificial intelligence (AI) tools for predicting which lung cancer patients will respond to immunotherapy.
A unique aspect of the Case Western Reserve-led study is that it will involve testing of their specific AI tools-for the first time during an ongoing clinical trial.
Artificial Intelligence Identifies Lung Cancer Patients at Risk of Harm Caused by Immunotherapy
February 9, 2021
In a subset of patients diagnosed with non-small cell lung cancer (NSCLC), immunotherapy paradoxically exacerbates tumor growth and significantly shortens survival. Currently there are no clinically validated biomarkers that can identify patients at risk of this paradoxical response called “hyperprogression.”
Using artificial intelligence (AI) analysis of simple tissue scans, researchers at Case Western University claim they have discovered biomarkers that could tell which lung cancer patients might get worse from immunotherapy.
In addition to those who would benefit from immunotherapy, and those who might not, researchers and oncologists can now identify a third category of patients called hyper-progressors who would be harmed by the same immunotherapy, says Pranjal Vaidya, a PhD student in biomedical engineering and researcher at the university’s Center for Com