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AIRE relies on Z-DNA to flag gene targets for thymic T cell tolerization

AIRE is an unconventional transcription factor that enhances the expression of thousands of genes in medullary thymic epithelial cells and promotes clonal deletion or phenotypic diversion of self-reactive T cells1–4. The biological logic of AIRE’s target specificity remains largely unclear as, in contrast to many transcription factors, it does not bind to a particular DNA sequence motif. Here we implemented two orthogonal approaches to investigate AIRE’s cis-regulatory mechanis...
Las Vegas Association For Computational Linguistics Cell Biol Acids Res Computational Linguistics Computer Vision
Source: nature.com

Nextech3D.ai Announces Formation of AI Incubator and AI Acquisition & Development Division With Potential 2024 IPO Spin Out

12.03.2024 - TORONTO, ON / ACCESSWIRE / March 12, 2024 / Nextech3D.AI (OTCQX:NEXCF)(CSE:NTAR)(FSE:1SS), a Generative AI-Powered 3D model supplier for Amazon, P&G, Kohls and other major e-commerce retailers announces the launch of its new AI Incubator and AI ... Seite 1
Katyani Singh Amir Salimnia Evan Gappelberg Ai Acquisition Development Division With Kai Development Division University Of Alberta

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