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Conserved and divergent gene regulatory programs of the mammalian neocortex

Divergence of cis-regulatory elements drives species-specific traits1, but how this manifests in the evolution of the neocortex at the molecular and cellular level remains unclear. Here we investigated the gene regulatory programs in the primary motor cortex of human, macaque, marmoset and mouse using single-cell multiomics assays, generating gene expression, chromatin accessibility, DNA methylome and chromosomal conformation profiles from a total of over 200,000 cells. From these data, we show ...
Las Vegas Initiative Cell Census Network International Multiple Sclerosis Genetics Consortium Association For Computing Machinery International Conference On Knowledge Discovery Human Gene Deserts
Source: nature.com

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