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Polθ is phosphorylated by PLK1 to repair double-strand breaks in mitosis

DNA double-strand breaks (DSBs) are deleterious lesions that challenge genome integrity. To mitigate this threat, human cells rely on the activity of multiple DNA repair machineries that are tightly regulated throughout the cell cycle1. In interphase, DSBs are mainly repaired by non-homologous end joining and homologous recombination2. However, these pathways are completely inhibited in mitosis3–5, leaving the fate of mitotic DSBs unknown. Here we show that DNA polymerase theta6 (Polθ...
United States Hela Gibco Biotinylated Pol Orbitrap Exploris Lipofectamine Rnaimax Thermofisher Jn Mark Glover
Source: nature.com

"Two-dimensional transient heat transfer model for high-temperature las" by Dasith Liyanage, Suk Chun Moon et al.

High-temperature laser-scanning confocal microscopy (HT-LSCM) has proven to be an excellent experimental technique through in situ observations of high temperature phase transformation to study kinetics and morphology using thin disk steel specimens. A 1.0 kW halogen lamp within the elliptical cavity of the HT-LSCM furnace radiates heat and imposes a nonlinear temperature profile across the radius of the steel sample. When exposed at the solid/liquid interface, this local temperature profile det...
Concentric Solidification Confocal Microscope Finite Element Analysis Igh Temperature Phase Transformation
Source: uow.edu.au

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"New insights of the peritectic phase transition in steel through in-si" by Suk Chun Moon, Dominic Phelan et al.

The topic of peritectic phase transition in steel has been widely studied using various in-situ experimental techniques including visual observation on a surface of a sample in a high temperature microscope and measurement of the thermal response from the bulk of the sample using differential thermal analysis (DTA) and differential scanning calorimetry (DSC). These two different techniques have inherent limitations leading to difficulties in interpretation of the results in the case of complex p...
Confocal Microscope In Situ Observation Thermal Analysis
Source: uow.edu.au

NASA Space Station On-Orbit Status 22 December, 2020 - Physics Phenomena

NASA Space Station On-Orbit Status 22 December, 2020 - Physics Phenomena Status Report - Source: SpaceRef NASA Space Station On-Orbit Status 22 December, 2020 - Physics Phenomena. The seven-member Expedition 64 crew, consisting of five astronauts and two cosmonauts, will spend the rest of the year conducting valuable space research aboard the International Space Station. Tuesdays slate of science investigations explored a range of space biology and physics phenomena to benefit hum...
Atlantic Ocean Nanoracks Bishop Rodent Research Flight Investigation Team International Space Spacex Cargo Dragon

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