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Neoadjuvant chemotherapy is the treatment of choice for newly diagnosed inflammatory or unresectable breast cancer, as well as locally advanced disease that might be rendered operable with neoadjuvant therapy, according to a new guideline from the American Society of Clinical Oncology (ASCO).
A limited number of factors have sufficient evidence to support routine use of clinical decision-making: tumor histology, grade, stage, and hormone receptor (HR) status (estrogen, progesterone, and HER2). Data remain insufficient to support use of other markers or genomic profiling to inform decisions about neoadjuvant chemotherapy, stated guideline panel co-chairs Larissa A. Korde, MD, of the National Cancer Institute in Bethesda, Maryland, and Dawn L. Hershman, MD, of Columbia University in New York City, and co-authors in the
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A fourth of previously treated cholangiocarcinomas (CCA) responded to a tyrosine kinase inhibitor (TKI) targeting the fibroblast growth factor receptor (FGFR) family, a phase II open-label study showed.
Confirmed objective responses occurred in 25 of 108 patients treated with infigratinib. Including unconfirmed responses increased the response rate to 34.2%. More than 80% of patients obtained disease control with FGFR inhibitor. Patients who had received no more than one prior systemic therapy responded better, but median progression-free survival (PFS, 7.3-7.4 months) was similar across prior lines of treatment.
Mechanism-based adverse events (AEs) predominated in the safety profile, notably hypophosphatemia and eye disorders, reported Milind Javle, MD, of the MD Anderson Cancer Center in Houston, at the Gastrointestinal Cancers Symposium virtual meeting.