Nuclear receptors FXR and SHP regulate protein N-glycan modifications in the liver
St3gal6 and St6gal1. Increased percentages of core-fucosylated and triantennary glycan moieties were seen in LDKO livers, and proteins with the “hyperglycoforms” preferentially localized to exosomes and lysosomes. This up-regulation of N-glycosylation machinery was specific to the Golgi apparatus and not the endoplasmic reticulum. The increased glycan complexity in the LDKO correlated well with dilated unstacked Golgi ribbons and alterations in the secretion of albumin, cholesterol, and tr...
United States Miltenyi Biotec Envigo Harlan Trizol Invitrogen Milliporesigma Amicon Vectashield Hardset
Source: sciencemag.org