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Princeton and MIT gene-editing pioneers uncover clues for improving CRISPR and other tools

Scientists at Princeton and MIT, including gene-editing pioneer David Liu, used a new screening method called Repair-seq to identify pathways that affect different outcomes in CRISPR/Cas9, prime editing and base editing. The findings could help design more accurate and efficient gene-editing systems, they say.
David Liu Broad Institute Massachusetts Institute Of Technology Princeton University Massachusetts Institute Nature Biotechnology

Temple research paves the way for first Phase 1/2 clinical trials of CRISPR-based therapy for HIV

For the last seven years, researchers at the Lewis Katz School of Medicine at Temple University have been developing and refining CRISPR-based gene-editing technology for the treatment of human immunodeficiency virus type 1 (HIV) infection.
Kamel Khalili Amyj Goldberg Laurah Carnell Triciah Burdo Emily Henderson Excision Biotherapeutics Inc

Novel CRISPR-based technology for rapidly screening genes to understand human health and disease

Zebrafish- small, fast-growing creatures who share many of the same genes as humans- are instrumental to many biologists, who find them uniquely well suited for studying a wide range of questions, from how organisms develop to how the nervous system drives behavior.
United States H Joseph Yost Randall Peterson Jing Ruey Joanna Yeh Calum Macrae Saba Parvez

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