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Researchers develop new tool for better classification of inherited disease-causing variants

Researchers from Childrens Hospital of Philadelphia (CHOP), the Perelman School of Medicine at the University of Pennsylvania, and the National Cancer Institute (NCI) of the National Institutes of Health have developed a new tool that allows scientists to annotate variant data from large-scale studies with clinically-focused classifications for risk of childhood cancer and other diseases. This new tool brings older applications in line with current guidelines and is available for use—f...
United States University Of Pennsylvania Jung Kim Pathogenicity Auto Jo Lynne Rokita Sharonj Diskin

The GPCR Puzzle: New Research Reveals Molecular Origins of Function for a Key Drug Target

Scientists at St. Jude Children's Research Hospital, collaborating internationally, used data science, pharmacology, and structural details to explore at the atomic level how each amino acid in the adrenaline-binding receptor affects its activity when interacting with this natural ligand. They di
United Kingdom United States Georgej Pedersen Maria Marti Solano Zhaowen Luo Manbir Sandhu

St. Jude researchers crack the code of the β2-adrenergic receptor

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.
United States United Kingdom M Madan Babu Franziska Heydenreich Michel Bouvier Maria Marti Solano

Researchers find gravitational lensing has significant effect on cosmic birefringence

Tokyo, Japan (SPX) Nov 03, 2023 - Future missions will be able to find signatures of violating the parity-symmetry in the cosmic microwave background polarization more accurately after a pair of researchers has managed to take into
Toshiya Namikawa Fumihiro Naokawa University Of Tokyo Department Physics Kavli Institute For The Physics Research Center Standard Model

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Sociodemographic characteristics and longitudinal progression of multimorbidity: A multistate modelling analysis of a large primary care records dataset in England

In this multistate modelling analysis, Sida Chen and colleagues examine sociodemographic characteristics and longitudinal progression of multimorbidity using data from primary care records in England
United Kingdom West Midlands United Kingdom General City Of Singula Bio Astra Zeneca
Source: plos.org

Open-analysis platform for pediatric brain tumors provides robust data resource for childhood cancer research

Researchers have partnered to create a first-of-its-kind open-source, reproducible analysis platform for pediatric brain tumors. With the help of thousands of genomically sequenced samples, researchers have used this platform to identify initial findings about genetic variants associated with poorer outcomes that could help guide future diagnostic and therapeutic advances.
San Francisco United States Jo Lynne Rokita Jay Scott Anna Kinderkrebsforschung Jaclynn Taroni

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