Hemorrhoidal disease (HD) is a form of an anorectal disease characterized by symptomatic enlargement and/or distal displacement of the healthy anal cushions known as hemorrhoids (1). Alarmingly, one.
Type 2 diabetes accounts for nearly 90% of the approximately 537 million cases of
diabetes worldwide. The number affected is increasing rapidly with alarming trends
in children and young adults (up to age 40 years). Early detection and proactive management
are crucial for prevention and mitigation of microvascular and macrovascular complications
and mortality burden. Access to novel therapies improves person-centred outcomes beyond
glycaemic control. Precision medicine, including multiomics and pharmacogenomics,
hold promise to enhance understanding of disease heterogeneity, leading to targeted
therapies.
Bothersome vasomotor symptoms (ie, hot flashes or flushes and night sweats) are common
after breast cancer, sometimes aggravated by chemotherapy-induced premature menopause
or adjuvant endocrine treatments. Consequently, there is a long history of clinical
trials testing a variety of centrally acting agents, including selective serotonin
reuptake inhibitors, selective norepinephrine reuptake inhibitors, gabapentin, and
others,1,2 to manage vasomotor symptoms when menopausal oestrogen therapy (transdermal
or oral oestrogens) is contraindicated.
During VV ECMO, there was no universally accepted threshold for transfusion, but PRBC
transfusion was invariably associated with lower mortality only when done with haemoglobin
concentration of less than 7 g/dL.
All GPs have patients with fertility problems who, at some point, may need advice, investigations organised and appropriate referral. This article, written by Olivia Stuart, provides an overview of the optimal lifestyle and medical advice for men and women, discusses the best predictors of fertility, and presents the relevant investigations and latest treatment options