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Novel Approach Described for Attacking Herpesviruses

Although HIV integrase inhibitors have been reported to inhibit replication of herpesviruses, a research team found the integrase inhibitors exhibited weak overall anti-HSV-1 activity. However, the researchers discovered that 8-hydroxyquinolones displayed strong antiviral activity against both HSV-1 and CMV and could inhibit one or more of the two-metal ion-dependent enzymes, thus opening the possibility of potentially developing dual targeting agents against herpesviruses.
Dennis Wright Sandrak Weller School Of Medicine School Of Pharmacy University Of Connecticut School Medicine University Of Connecticut

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