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Closer to human -- Mouse model more accurately reproduces fatty liver disease

 E-Mail Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. "NAFLD has been difficult to study mainly because we had no good animal model," said corresponding author Dr. Karl-Dimiter Bissig, who was at Baylor during the development of this project and is now at Duke University. The disease has both genetic and nutritional components, which have...
United States Baylor College Of Medicine Karl Dimiter Bissig Scotta Ochsner Malgorzata Borowiak Beatrice Bissig Choisat

Closer to human – mouse model more accurately reproduces fatty liver disease

Closer to human – mouse model more accurately reproduces fatty liver disease Human non-alcoholic fatty liver disease (NAFLD) is a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. A chimeric mouse model of NAFLD. On the left, a microscopy image of H&E-stained chimeric liver sections showing separation of liver cells from human or murine origin. Note that the fatty, white filling i...
United States Baylor College Of Medicine Karl Dimiter Bissig Scotta Ochsner Malgorzata Borowiak N Thaon Galvan
Source: bcm.edu

Mouse model closely reproduces human fatty liver disease

Date Time Mouse model closely reproduces human fatty liver disease A team at Baylor College of Medicine and other institutions has developed a novel mouse model that reproduces many key features of human non-alcoholic fatty liver disease (NAFLD), a little-understood condition that significantly increases the risk of inflammation, fibrosis and liver cancer and ultimately requires liver transplant. With this model, researchers have an opportunity to advance the understanding and treatment of this...
United States Baylor College Of Medicine Karl Dimiter Bissig Scotta Ochsner Malgorzata Borowiak Beatrice Bissig Choisat

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