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In particular, it could work on biological samples in water, opening the door to what has become a huge area of current biological and biomedical research: AFM of biological processes to understand things such as the mechanism of action of antimicrobial peptides.
It is the highest resolution microscopy available for biological samples in water, other than that of another technology he co-invented, called Scanning Ion Conductance Microscopy (SICM). SICM is more difficult to use than AFM and so, thus far, is only used by specialists.
He collaborated with fellow physics professor Virgil Elings, who started a company, licensed Hansma’s UCSB patent, and produced the world’s first commercial AFM, the Multimode.