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Venetoclax Plus Dexamethasone Misses PFS End Point in t(11;14)+ R/R Multiple Myeloma

The combination of venetoclax and dexamethasone failed to significantly improve progression-free survival over pomalidomide plus dexamethasone in patients with t(11;14)-positive, relapsed or refractory multiple myeloma who have previously received at least 2 therapies.
San Diego United States Noord Holland Venclexta Venclyxto Mariana Cota Stirner International Myeloma Working Group

Extended Melphalan Flufenamide Indication Approaches EU Approval for R/R Multiple Myeloma

The European Medicines Agency’s Committee for Medicinal Products for Human Use has adopted a positive opinion regarding a Type II variation application to extend the therapeutic indication of melphalan flufenamide for use in adult patients with multiple myeloma who have received at least 2 prior lines of treatment and whose disease is refractory to lenalidomide and the last line of therapy.
United States Oncologic Drugs Advisory Committee European Medicines Agency Medicinal Products Human Use Drugs Advisory Committee

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