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Intravacc announces positive preclinical data for its SARS- CoV-2 nose spray vaccine
Intranasal administration of OMV-Spike protected against challenge with SARS-CoV-2
Intranasal vaccine administration has significant advantages over injectables
OMV technology is a powerful vaccine platform for future pandemics
Bilthoven, The Netherlands, 7 April 2021 – Intravacc, a global leader in translational research and development of viral and bacterial vaccines, today announced that it has obtained positive preclinical results for its SARS-CoV-2 Outer Membrane Vesicle (OMV) based recombinant Spike protein (rSp) candidate nose spray vaccine.
For the preclinical study four groups of mice and four groups of hamsters received two intranasal immunizations on day one and day 21. One group of mice and hamsters received a vaccine based on OMV’s mixed with rSp (CovOMV) and the other a vaccine based on OMV’s coupled to rSp based on Intravacc’s proprietary OMV click technology (CovOMVcl