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Eli Lilly said the SURPASS-3 and SURPASS-5 phase III clinical trials showed that the once-weekly glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptor agonist tirzepatide significantly reduced HbA1c and body weight in adults with type 2 diabetes meeting both trials primary and key secondary endpoints.
In other trial success, the SKYLIGHT 1 and SKYLIGHT 2 phase III clinical trials also met all their primary endpoints with the investigational, oral, nonhormonal compound fezolinetant for moderate to severe vasomotor symptoms of menopause, Astellas announced.
Girls with overweight and obesity tended to have higher levels of certain hormones like follicle-stimulating hormone, inhibin B, and testosterone during puberty compared with normal weight girls. In some girls with higher total body fat, higher testosterone levels were associated with irregular menstrual cycles, acne, and excess body hair, added study author Natalie Shaw, MD,