slim, in general if the you talk in generality, you talk about two years or so for survival. but there are people who are living ten years, about five years depending on some very specific markers. and so his location was a good location to get a long-term good prognosis. arthel: well, that s encouraging regarding senator mccain. finally, doctor, are there certain symptoms, you know? how would one s doctor mow how the find this or discover it? what do you say to the doctor, i ve got a headache? what is it? so a lot of time you might find something is subtle that family might pick it up; behavioral changes, speech problem, vision problem, balance problem. so anything that is neurologically changed. for example, we did see some of those subtle deficits and kind of speech impediment with senator mccain that kind of gave you a clue that something in the left frontal lobe is