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EXPLAINED: What is Switzerland s animal testing referendum all about?

EXPLAINED: What is Switzerland s animal testing referendum all about?
thelocal.ch - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from thelocal.ch Daily Mail and Mail on Sunday newspapers.

Renato werndliYves fluckigerSamia hurstPierre bonnaventureDoron merklerPatrycja nowak sliwinskaUniversity of genevaProfessor doron merkler

Colder Temperature Eases Inflammation, MS Severity in Mouse Model

Colder Temperature Eases Inflammation, MS Severity in Mouse Model
multiplesclerosisnewstoday.com - get the latest breaking news, showbiz & celebrity photos, sport news & rumours, viral videos and top stories from multiplesclerosisnewstoday.com Daily Mail and Mail on Sunday newspapers.

Doron merklerMirko trajkovskiUniversity of geneva

Multiple Sclerosis Symptoms Ease at Cold Temperatures in Mice

Scientists at the University of Geneva (UNIGE) showed that colder temperatures provoke a trade-off of energy resources between autoimmunity and thermogenesis in mice. Cold decreases the antigen-presenting protein major histocompatibility complex class II (MHCII) on monocytes at steady state and in various inflammatory conditions including in a mouse model of multiple sclerosis. In addition, cold suppresses T-cell priming and pathogenicity against the body’s own antigens through the modulation of monocytes, thereby reducing neuroinflammation in mouse models of multiple sclerosis.

Doron merklerMirko trajkovskiUniversity of genevaDiabetes centreCentre for inflammation researchCell metabolismExposure protectsInflammation research

Scientists show how cold could alleviate multiple sclerosis symptoms

In evolutionary biology, the "Life History Theory", first proposed in the 1950s, postulates that when the environment is favorable, the resources used by any organism are devoted for growth and reproduction.

Doron merklerMirko trajkovskiEmily hendersonDiabetes centre at faculty of medicineDepartment of pathologyUniversity of genevaCentre for inflammation researchDepartment of cellular physiologyCell metabolismCellular physiologyDiabetes centreInflammation researchMultiple sclerosisAutoimmune diseaseCell metabolismCentral nervous system

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model

Inflammation of the brain gray matter decreases nerve-cell activity in mouse model Damage to the brain gray matter plays an important role in the progression of multiple sclerosis. This study now shows that such damage can be caused by inflammatory reactions that lead to loss of synapses, which impairs neural activity. Multiple sclerosis (MS) is a chronic inflammatory disease that affects the central nervous system, in which nerve cells are attacked by the patient s own immune system. In many cases, the disease develops into a progressive form, which is characterized by a shift of pathology from the white matter to the gray matter, for instance to the cerebral cortex.

Martin kerschensteinerDoron merklerEmily hendersonDoron merkler university of genevaThomas misgeld technical university of munichUniversity of genevaInstitute for clinical neuroimmunologyClinical neuroimmunologyThomas misgeldTechnical universityMultiple sclerosisCentral nervous systemImmune systemInflammatory diseaseMouse modelNervous system