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Or tongue swelling rash; itching; or hives have happened. tell your doctor about dental problems as severe jaw bone problems may happen or new or unusual pain in your hip groin, or thigh, as unusual thigh bone fractures have occurred. speak to your doctor before stopping prolia® as spine and other bone fractures have occurred. prolia® can cause serious side effects, like low blood calcium; serious infections which could need hospitalization; skin problems; and severe bone joint, or muscle pain...