unfolding in the banking sector has boosted the odds of a recession in the u.s. within the next year. but treasury secretary janet yellen is about to wrap up her senate testimony and she argued the fallout has been contained. i can reassure the members of the committee that our banking system is sound and that americans can feel confident that their deposits will be there when they need them. this week s actions demonstrate our resolute commitment to ensure that our financial system remains strong and that depositors savings remain safe. now, the market seemed skeptical until they got word that chase and morgan stanley are considering rescuing the struggling first republic bank. regional bank stocks are mixed, which is actually a major improvement from earlier today. elsewhere in the economy some promising new data on jobs and mortgage rates. we have cnn s matt egan, who s here once again to help make heads or tails of all of this for us. okay, matt, let s start here wit
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One Site for Seniors, an adult day center in Coeur d’Alene, celebrated Valentine’s Day with music, decorations, paper hearts, dancing, games and food with about 20 guests.
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Gram-negative bacteria are extraordinarily difficult to kill because their cytoplasmic membrane is surrounded by an outer membrane that blocks the entry of most antibiotics. The impenetrable nature of the outer membrane is due to the presence of a large, amphipathic glycolipid called lipopolysaccharide (LPS) in its outer leaflet1. Assembly of the outer membrane requires transport of LPS across a protein bridge that spans from the cytoplasmic membrane to the cell surface. Maintaining outer membrane integrity is essential for bacterial cell viability, and its disruption can increase susceptibility to other antibiotics2–6. Thus, inhibitors of the seven lipopolysaccharide transport (Lpt) proteins that form this transenvelope transporter have long been sought. A new class of antibiotics that targets the LPS transport machine in Acinetobacter was recently identified. Here, using structural, biochemical and genetic approaches, we show that these antibiotics trap a substrate-bou
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