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Researchers discover PPFIA3 gene as a cause of previously unknown syndromic neurodevelopmental disorder

An international collaborative study led by postdoctoral scientist, Dr. Maimuna Paul, and child neurologist, Dr. Hsiao-Tuan Chao, an assistant professor at Baylor College, a faculty member with the Cain Pediatric Neurology Research Foundation Laboratories at the Jan and Dan Duncan Neurological Research Institute (Duncan NRI) at Texas Children's Hospital, and an investigator at the McNair Medical Institute with The Robert and Janice McNair Foundation, recently discovered that variants in the ...
United States Maimuna Paul Hsiao Tuan Chao Baylor College Cain Pediatric Neurology Research Foundation Laboratories Diseases Network

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Eastern equine encephalitis virus study uncovers decoy molecule that protects against deadly brain infection

An atomic-level investigation of how Eastern equine encephalitis virus binds to a key receptor and gets inside of cells also has enabled the discovery of a decoy molecule that protects against the potentially deadly brain infection, in mice.
Lucas Adams Davedh Fremont Saravanan Raju Herberts Gasser Professor At Washington University Washington University School Of Medicine University School

Study identifies α-MSH as therapeutic candidate for corneal endothelial disease

Findings from a pioneering study in The American Journal of Pathology, published by Elsevier, reveal that administration of the neuropeptide α-melanocyte-stimulating hormone (α-MSH) promotes corneal healing and restores normal eye function to an otherwise degenerating and diseased cornea by providing protection against cell death and promoting cell regeneration.
United States Reza Dana Refractive Surgery Service At Mass Eye American Journal Mass Eye Harvard Medical School Department

St. Jude researchers crack the code of the β2-adrenergic receptor

Through an international collaboration, scientists at St. Jude Children's Research Hospital leveraged data science, pharmacology and structural information to conduct an atomic-level investigation into how each amino acid in the receptor that binds adrenaline contributes to receptor activity in the presence of this natural ligand.
United States United Kingdom M Madan Babu Franziska Heydenreich Michel Bouvier Maria Marti Solano

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