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New approach to CAR T cell therapy may extend treatment effectiveness

CAR T cell therapy, a powerful type of immunotherapy, has begun to revolutionize cancer treatment. Pioneered at Memorial Sloan Kettering Cancer Center (MSK), the therapy involves engineering a patient's T cells so they recognize and attack cancer cells.
Zeguo Zhao Michel Sadelain Nayan Jain Sloan Kettering Institute Memorial Sloan Kettering Cancer Center Epigenetics Research

Gene therapy's double-edged sword: Breakthrough treatments face manufacturing and efficacy

Research explores the advancements, challenges, and economic implications of gene therapy for various diseases, including inherited blood disorders, malignancies treated with CAR-T cells, and diseases targeted by in vivo AAV vectors. The review highlights the transformative potential of gene therapies while acknowledging the complexities in manufacturing, safety, efficacy, and long-term durability.
Drug Administration Contract Development Gene Therapy Major Histocompatibility Complex B Cell Maturation Antigen Inverted Terminal Repeats

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