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DNA sequencing of residual disease accurately identifies leukemia patients who would relapse

In pediatric and young adult patients with acute lymphoblastic leukemia (ALL) treated with tisagenlecleucel (Kymriah), DNA sequencing-based detection of residual disease between three and 12 months accurately identified all patients who would eventually relapse, while other methods were less predictive.
University Of Pennsylvania United States City Of United Kingdom Jack Bartram Sara Ghorashian

Olema Pharmaceuticals, Inc. Announces First Clinical Data on OP-1250 in?Advanced ER+ / HER2- Breast Cancer

Olema Pharmaceuticals, Inc. announced the first clinical data from the Phase 1 dose-escalation portion of the ongoing Phase 1/2 clinical trial of OP-1250, a complete estrogen receptor antagonist and... | December 1, 2021
Olema Pharmaceuticals Inc Olema Pharmaceuticals Interim Results Dose Escalation Nc Stock Exchange Press Release

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Human LRRC15 protein is an inhibitory receptor for SARS-CoV-2 spike-mediated entry

In a recent study, published on the bioRxiv* preprint server, researchers identified human LRRC15 as an inhibitory receptor for SARS-CoV-2 entry, which directly binds to the receptor-binding domain (RBD) of the spike protein with a moderate affinity and inhibits spike-mediated entry.
Dotted Yeti Coronavirus Disease Covid 19 Ars Cov 2 Ngiotensin Converting Enzyme 2 Flow Cytometry Hela Cells

Study shows plasmacytoid dendritic cells may be a viable target for protection against SARS-CoV-2

A recent research paper by scientists from Denmark reveals that circulating plasmacytoid dendritic cells may be a potential therapeutic target to maintain desired levels of an antiviral compound known as interferon, allowing for the mitigation of coronavirus disease (COVID-19) severity. The study is currently available on the bioRxiv* preprint server while it undergoes peer review.
Aarhus University Image Credit Coronavirus Disease Covid 19 Ars Cov 2 Immune Response Immune System

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