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City of Hope researchers identify how breast cancer cells acquire resistant traits

City of Hope, a world-renowned cancer research and treatment center, has identified how cancer cells in patients with early-stage breast cancer change and become resistant to hormone or combination therapies, according to a new study published in Nature Cancer.
United States Andrea Bild Suwon Kim Emily Henderson Translational Genomics Research Institute Tgen University Of Arizona College Medicine

Regeneron mAb cocktail benefits hospitalized patients with no natural SARS-CoV-2 antibody response

Regeneron mAb cocktail benefits hospitalized patients with no natural SARS-CoV-2 antibody response Researchers reporting on findings from the Randomized Evaluation of COVID-19 Therapy (RECOVERY) trial in the UK are recommending that any therapeutic use of REGEN-COV may be best restricted to individuals without detectable antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The RECVORY Collaborative Group says that among patients hospitalized with coronavirus disease ...
United States United Kingdom Peter Horby Sally Robertson Collaborative Group University Of Oxford

Adding immune oncology drug to chemotherapy improves response in subset of breast cancer patients

In a new study by researchers at Yale Cancer Center, combining the immunotherapy drug durvalumab and PARP-inhibitor olaparib with chemotherapy improved response to treatment for women with high-risk, HER2-negative breast cancer, including a subset of estrogen receptor positive cancers.
Emily Henderson Yale Cancer Center Drug Administration Medical Oncology Breast Cancer Translational Research Triple Negative Breast Cancer

Humoral innate pattern recognition molecules against SARS-CoV-2

In a paper recently uploaded to the preprint server medRxiv by Garlanda et al. (June 8th, 2021), humoral pattern recognition molecules are explored for affinity towards SARS-CoV-2, contributing to unraveling the role of these molecules in COVID-19 disease progression.
Michael Greenwood Carbohydrate Recognition Domain Ars Cov 2 Coronavirus Disease Covid 19 Hepatitis C Herpes Simplex

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Forkhead box O's potential therapeutic use in the treatment of COVID-19

Forkhead box Os potential therapeutic use in the treatment of COVID-19 In a recent study, Indian researchers from the Department of Biochemistry, University of Delhi, reviewed a possible vital coalition of FoxOs - the Forkhead Box O subfamily of protein transcription factors, with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), the etiological agent of COVID-19 (coronavirus disease). This review work is posted in the journal, Open Biology, published by the Royal Society. While mo...
Ramya Dwivedi Royal Society University Of Delhi Department Of Biochemistry Open Biology Acute Respiratory Distress Syndrome

What makes the elderly more susceptible to SARS-CoV-2 infection?

Why is severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19 (coronavirus disease 2019), biased towards infecting the aged population? A recently published study by Italian scientists linked aging, DNA damage, telomere shortening, and increased levels of angiotensin-converting enzyme 2 (ACE2) to this relationship.
Ramya Dwivedi Kateryna Kon Shutterstock Kateryna Kon Image Credit Nature Cell Biology Ars Cov 2

Statins associated with reduced COVID-19 mortality and decreased need for ventilator support

Statins are medications widely used in the management of cardiovascular diseases and metabolic syndrome. Statins help lower serum lipids by blocking HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase), the rate-limiting enzyme of cholesterol biosynthesis.
Susha Cheriyedath Image Credit Ngiotensin Converting Enzyme 2 Coronavirus Disease Covid 19 Metabolic Syndrome Ars Cov 2

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