Page 212 - Eceptor News Today

Although Peru is one of the countries most affected by the pandemic, no studies had been conducted to investigate SARS-CoV-2 seroprevalence among domestic cats. Recently, researchers from Peru demonstrated the presence of neutralizing antibodies for the receptor binding-domain (RBD) of the SARS-CoV-2 spike protein in cats in Lima, Peru. The owners of the cats in the study had confirmed SARS-CoV-2 infection.

Researchers from the US tested the prophylactic potential of a combination of 2 mAbs administered 3 or 75 days before respiratory challenge in rhesus macaques. They used the rhesus macaque model to test the added benefit of combinatory parenteral administration of 2 high-affinity anti-SARS-CoV-2 mAbs - C144-LS and C135-LS. These mAbs were developed to neutralize the virus and tweaked to improve their pharmacokinetics.

Researchers identify common epitopes across SARS-CoV-2 viral variants Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative pathogen of the coronavirus 2019 (COVID-19) pandemic. To date, over 170 million cases have been confirmed worldwide, resulting in over 3.55 million deaths. While several vaccine candidates have been developed and deployed to arrest the spread of SARS-CoV-2, concern among scientists and public health authorities is mounting over the immunity escape p...

A novel multi-epitope COVID-19 vaccine developed using reverse vaccinology In late December 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, and subsequently spread rapidly across the world. On the 11th of March 2020, the World Health Organization announced the global outbreak of coronavirus disease 2019 (COVID-19) as a pandemic. Scientists around the world are working extensively to develop new vaccines, therapeutics, and many other strategies to cont...

Novel protein interactions with ACE2 disrupted by SARS-CoV-2, contributes to COVID-19 pathologies The novel coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused severe morbidity and mortality across the world. Other than flu-like symptoms of respiratory disease, SARS-CoV-2 infection can also cause systemic manifestations, leading to a wide range of pathologies, including thrombosis and microvascular injury and stroke, vascular system disruption, gastrointestinal c...

Researchers at the Department of Viroscience, Erasmus MC, National Institute for Public Health and the Environment, Amsterdam UMC, and the Weill Medical College of Cornell University studied humoral and cellular immune responses to the wild type SARS-CoV-2, the B.1.1.7 variant (U.K. variant) and the B.1.351 variant (South African variant) in health care workers vaccinated with the BNT162b2 (Pfizer-BioNTech) mRNA vaccine.

A recent report by a team of researchers focused on the extent of convergent evolution in the SARS-CoV-2 spike (S) protein. The report confirms that top SARS-CoV-2 lineages of concern have the most convergent spike protein mutations. This indicates their fundamental adaptive advantage.

Recently, researchers from the UK and Sweden used highly sensitive multiplexed immunohistochemistry to study the brain tissue of COVID-19 patients and controls to analyze ACE2 expression in brain pericytes of patients with neurological symptoms. They also used spatial immunophenotyping to assess inflammation in brain tissue of COVID-19 patients.

In a new study posted to the bioRxiv* preprint server, a prospective cohort of patients with COVID-19 exhibited distinct features of the IgG fragment antigen-binding (Fab) and fragment crystallizable (Fc) domains, predicting two distinct disease trajectory two days after a positive test.

Plexin-A1 gene plays a more extensive role in brain development, study shows Study by the University of Bonn shows that mutations of the investigated gene manifest in different patterns of inheritance. The so-called Plexin-A1 gene seems to play a more extensive role in brain development than previously assumed. This is shown by a current study led by the University Hospital Bonn and the Institute of Anatomy of the University of Bonn with more than 60 international partners. The gene is also int...