Page 215 - Eceptor News Today

Study could serve as guidepost for developing new therapies for Alzheimers disease In a major breakthrough, researchers at Massachusetts General Hospital (MGH) have discovered how amyloid beta--the neurotoxin believed to be at the root of Alzheimers disease (AD)--forms in axons and related structures that connect neurons in the brain, where it causes the most damage. Their findings, published in Cell Reports, could serve as a guidepost for developing new therapies to prevent the onset of this ...

New peptides allow cannabis-derived drugs to fight pain in mice without side effects An international team, led by researchers from Pompeu Fabra University (UPF) in Barcelona, Spain, David Andreu and Rafael Maldonado, has developed a peptides family that allows delta-9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, to fight pain in mice without side effects. The study, published in the Journal of Medicinal Chemistry, was carried out together with researchers from the Autono...

India’s surge in SARS-CoV-2 infections are linked to the new variants B.1.617 and B.1.618, with mutated spike proteins.

DNAM-1 receptor could be used as new molecular target for treating autoimmune diseases Autoimmune diseases occur when an individuals immune system fights their own body as if it was a foreign invader. However, in healthy people, these responses are prevented by a process known as immune tolerance. Many complex biological mechanisms maintain the necessary balance between immune activation and suppression to ensure immune tolerance does not prevent the body from effectively fighting pathogens. In...

New research published on the preprint server bioRxiv* suggests S2-specific antibody responses are critical in recovering from mild to severe COVID-19 infection. Compared to patients who died within 28 days of their COVID-19 diagnosis, patients who produced a wide range of S2-specific responses were more likely to survive.

Milder COVID-19 in children may be due to higher memory B cells responses to SARS-CoV-2 The importance of durable immunity against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become increasingly evident, particularly as newer strains of the virus emerge, which are sometimes more infectious or partially resistant to neutralization by the antibodies produced by earlier strains. A new research paper published in the journal Science explores the differences in coronavirus-...

A SARS-CoV-2 ferritin nanoparticle vaccine elicits broad immunity COVID-19 (coronavirus disease 2019) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), displaying high mortality rates. Responsible for over 3.34 million deaths the world over, the virus continues to rage on in many countries. Due to the rise of variants of concern (VoC) and the long-term threat of other emerging coronaviruses in the near future, a comprehensive and effective pandemic response strategy is ...

A look at how coronavirus disease (COVID-19) affects Parkinsons The coronavirus disease 2019 (COVID-19) pandemic has caused immense devastation, with well over three million reported deaths, hundreds of millions of infections, and drastic reductions in economic growth worldwide. As a result of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, not only acute symptoms have been noted, but also long-term complications. Earlier, herpes simplex virus (HSV), influenza virus ...

Designer SARS-CoV-2 RBD vaccine produces dramatically improved antibody response in preclinical trials The importance of computational modeling in the prediction of the course of the ongoing coronavirus disease 2019 (COVID-19) pandemic, as well as evaluating multiple potential drug leads, has never been more clear. Now, a new study describes a set of designer vaccine antigens that may improve vaccine stability as well as enhance the neutralizing antibody response. The virus causing this pandemi...

New peptide could allow cannabis to fight pain without side effects Many people live with chronic pain, and in some cases, cannabis can provide relief. But the drug also can significantly impact memory and other cognitive functions. Now, researchers reporting in ACS Journal of Medicinal Chemistry have developed a peptide that, in mice, allowed Δ 9-tetrahydrocannabinol (THC), the main component of Cannabis sativa, to fight pain without the side effects. According to the U.S. Centers for Disea...